Survey of Penicillia associated with Italian grana cheese

The present work aimed to contribute information on the mycobiota associated with ripening grana cheese, with focus on the genus Penicillium as potential mycotoxin producers. Eighteen wheels of grana cheese, aged in different storehouses situated in Northern Italy, were sampled to isolate associated fungi. Penicillium spp. were commonly dominant; morphological observation and gene sequencing were applied to identify Penicillium at species level. P. crustosum and P. solitum were the dominant species. Citrinin and ochratoxin A mycotoxins were analysed and the latter was found in all grana cheese samples. These results confirmed that a polyphasic approach is mandatory for Penicillium identification at species level.The present work was supported by the following institutions: Consorzio del Formaggio Parmigiano Reggiano, Consorzio per la tutela del Formaggio Grana Padano, Fondazione Romeo ed Enrica Invernizzi. The authors thank Prof. Terenzio Bertuzzi (Food Science and Nutrition Institute, Università Cattolica del Sacro Cuore, Piacenza, Italy) for mycotoxins analysis and Dr. Célia Soares (Centre of Biological Engineering, Universidade do Minho, Braga, Portugal) for preservation and depositing working at MUM

Formação e ministério pastoral na Igreja Evangélica de Confissão Luterana no Brasil (IECLB); informações e comentários sobre uma pesquisa social

Sem relação direta com o tema “Catecumenato Permanente”, mas ainda dentro do tema “formação”, apresentamos na sequência um artigo sobre “Formação e Ministério Pastoral na Igreja Evangélica de Confissão Luterana no Brasil (IECLB)”, que traz o subtítulo “Informações e Comentários sobre uma Pesquisa Social”, escrito por Nelson Kirst e Mauro Schwalm (Mauro é doutorando do Instituto Ecumênico de Pós-graduação da EST)

Programación en entornos visuales, técnicas para la iniciación a la programación y una referencia a experiencias realizadas con distintas franjas etarias

En este trabajo detallaremos aspectos de la programación en entornos visuales basados en las herramientas de desarrollo Scratch y App Inventor. Estas herramientas fueron probadas con un variado segmentos de usuarios que abarcaron público con edades que van de los 9 a 50 años, sin experiencia alguna en programación, y desarrollados en la localidad de Río Gallegos.Eje: Educación en Tecnología.Red de Universidades con Carreras en Informática (RedUNCI

Lessons learned from the use of the SlideWiki OpenCourseWare platform in different learning contexts

A major obstacle to increasing the efficiency, effectiveness and quality of education is the lack of widely available, accessible, multilingual, timely, engaging and high-quality educational material, i.e. OpenCourseWare (OCW). The creation of comprehensive OCW is often a tedious, time-consuming and expensive process, with the effect that courseware employed by educators and trainers can be incomplete and outdated, as well as inaccessible to those with disabilities. With the open-source and open-access SlideWiki platform, the effort of creation, translation and evolution of highly-structured remixable OCW can be widely shared. Similarly to Wikipedia for encyclopaedic content, SlideWiki allows to collaboratively create comprehensive OCW (curricula, slide presentations, self-assessment tests, illustrations etc.) online in a crowdsourcing manner. SlideWiki has won the OpenCourseWare Consortium’s Excellence Award and is used by hundreds of educators and thousands of learners. Several hundred comprehensive course materials are available on SlideWiki in different languages. The SlideWiki large-scale trial project is further maturing the SlideWiki platform by improving its usability and accessibility. The SlideWiki project is performing a wide range of trials covering different levels of education (i.e. from secondary to higher education) and different types of learning (i.e. formal learning, informal learning, vocational learning). Each of these large-scale trials is carried out with hundreds of educators and thousands of learners in different countries across Europe. A particular focus of the technology development and testing in the trials is the suitability for academics, teachers and learners with disabilities. This paper will present the lessons learned from piloting the SlideWiki platform in different learning contexts and scenarios. In particular, we will describe the learning scenarios considered in each pilot and how these scenarios have been implemented with the use of SlideWiki. We will then describe the methodology followed in each pilot, in terms of the authoring, teaching and learning activities performed by educators and learners using SlideWiki. Finally, the lessons learned from each pilot will be discussed, focusing on the challenges faced in each pilot, how these challenges have been addressed, as well as the best practices that have emerged from the pilots regarding the collaborative authoring and sharing of OCW

Heterogeneidade dos cordomas intracranianos: : relato de dois casos

Chordomas are very rare primitive notochord-related tumors localized most frequently in sacrococcygeal and cranial regions. Intracranial lesions correspond to 3-5% of the primary tumors. Clinical management is very difficult; surgical ressection is usually incomplete, and can be associated with rapid tumor growth and multiple neurological involvement. In this study, the authors report on two cases of intracranial chordomas with diverse presentation and evolution, and discuss the diagnosis and the management of these patients.Cordomas são neoplasias raras originadas da notocorda primitiva, que se localizam predominantemente em região sacroccígena e menos freqüentemente intracranianas, correspondendo de 3 a 5% dos tumores primários cerebrais. Os cordomas intracranianos são de manejo difícil, a ressecção cirúrgica geralmente é incompleta e os pacientes podem evoluir para óbito em decorrência do crescimento incontrolável do tumor e/ou compressão de estruturas nobres adjacentes. Neste trabalho os autores relatam dois pacientes com cordoma intracraniano cuja evolução clínica foi absolutamente distinta, dissertando sobre os diversos aspectos relacionados ao diagnóstico, tratamento e evolução dos dois casos

International Coercion, Emulation and Policy Diffusion: Market-Oriented Infrastructure Reforms, 1977-1999

Why do some countries adopt market-oriented reforms such as deregulation, privatization and liberalization of competition in their infrastructure industries while others do not? Why did the pace of adoption accelerate in the 1990s? Building on neo-institutional theory in sociology, we argue that the domestic adoption of market-oriented reforms is strongly influenced by international pressures of coercion and emulation. We find robust support for these arguments with an event-history analysis of the determinants of reform in the telecommunications and electricity sectors of as many as 205 countries and territories between 1977 and 1999. Our results also suggest that the coercive effect of multilateral lending from the IMF, the World Bank or Regional Development Banks is increasing over time, a finding that is consistent with anecdotal evidence that multilateral organizations have broadened the scope of the “conditionality” terms specifying market-oriented reforms imposed on borrowing countries. We discuss the possibility that, by pressuring countries into policy reform, cross-national coercion and emulation may not produce ideal outcomes.http://deepblue.lib.umich.edu/bitstream/2027.42/40099/3/wp713.pd

Variability in Serum Sodium Concentration and Prognostic Significance in Severe Traumatic Brain Injury: A Multicenter Observational Study.

BACKGROUND/OBJECTIVE: Dysnatremia is common in severe traumatic brain injury (TBI) patients and may contribute to mortality. However, serum sodium variability has not been studied in TBI patients. We hypothesized that such variability would be independently associated with mortality. METHODS: We collected 6-hourly serum sodium levels for the first 7 days of ICU admission from 240 severe TBI patients in 14 neurotrauma ICUs in Europe and Australia. We evaluated the association between daily serum sodium standard deviation (dNaSD), an index of variability, and 28-day mortality. RESULTS: Patients were 46 ± 19 years of age with a median initial GCS of 6 [4-8]. Overall hospital mortality was 28%. Hypernatremia and hyponatremia occurred in 64% and 24% of patients, respectively. Over the first 7 days in ICU, serum sodium standard deviation was 2.8 [2.0-3.9] mmol/L. Maximum daily serum sodium standard deviation (dNaSD) occurred at a median of 2 [1-4] days after admission. There was a significant progressive decrease in dNaSD over the first 7 days (coefficient - 0.15 95% CI [- 0.18 to - 0.12], p < 0.001). After adjusting for baseline TBI severity, diabetes insipidus, the use of osmotherapy, the occurrence of hypernatremia, and hyponatremia and center, dNaSD was significantly independently associated with 28-day mortality (HR 1.27 95% CI (1.01-1.61), p = 0.048). CONCLUSIONS: Our study demonstrates that daily serum sodium variability is an independent predictor of 28-day mortality in severe TBI patients. Further prospective investigations are necessary to confirm the significance of sodium variability in larger cohorts of TBI patients and test whether attenuating such variability confers outcome benefits to such patients

Measurement of the Lifetime Difference Between B_s Mass Eigenstates

We present measurements of the lifetimes and polarization amplitudes for B_s --> J/psi phi and B_d --> J/psi K*0 decays. Lifetimes of the heavy (H) and light (L) mass eigenstates in the B_s system are separately measured for the first time by determining the relative contributions of amplitudes with definite CP as a function of the decay time. Using 203 +/- 15 B_s decays, we obtain tau_L = (1.05 +{0.16}/-{0.13} +/- 0.02) ps and tau_H = (2.07 +{0.58}/-{0.46} +/- 0.03) ps. Expressed in terms of the difference DeltaGamma_s and average Gamma_s, of the decay rates of the two eigenstates, the results are DeltaGamma_s/Gamma_s = (65 +{25}/-{33} +/- 1)%, and DeltaGamma_s = (0.47 +{0.19}/-{0.24} +/- 0.01) inverse ps.Comment: 8 pages, 3 figures, 2 tables; as published in Physical Review Letters on 16 March 2005; revisions are for length and typesetting only, no changes in results or conclusion

Two Remarkably Luminous Galaxy Candidates at z≈11−13z\approx11-13 Revealed by JWST

The first few hundred Myrs at $z>10$ mark the last major uncharted epoch in the history of the Universe, where only a single galaxy (GNz11 at $z\approx11$) is currently spectroscopically confirmed. Here we present a search for luminous $z>10$ galaxies with $JWST$/NIRCam photometry spanning $\approx1-5\mu$m and covering 49 arcmin$^{2}$ from the public $JWST$ Early Release Science programs (CEERS and GLASS). Our most secure candidates are two $M_{\rm{UV}}\approx-21$ systems: GLASS-z13 and GLASS-z11. These galaxies display abrupt $\gtrsim2.5$ mag breaks in their spectral energy distributions, consistent with complete absorption of flux bluewards of Lyman-$\alpha$ that is redshifted to $z\approx13$ and $z\approx11$. Lower redshift interlopers such as dusty quiescent galaxies with strong Balmer breaks would be comfortably detected at $>5\sigma$ in multiple bands where instead we find no flux. From SED modeling we infer that these galaxies have already built up $\sim 10^9$ solar masses in stars over the $\lesssim300-400$ Myrs after the Big Bang. The brightness of these sources enable morphological constraints. Tantalizingly, GLASS-z11 shows a clearly extended exponential light profile, potentially consistent with a disk galaxy of $r_{\rm{50}}\approx0.7$ kpc. These sources, if confirmed, join GNz11 in defying number density forecasts for luminous galaxies based on Schechter UV luminosity functions, which require a survey area $>10\times$ larger than we have studied here to find such luminous sources at such high redshifts. They extend evidence from lower redshifts for little or no evolution in the bright end of the UV luminosity function into the cosmic dawn epoch, with implications for just how early these galaxies began forming. This, in turn, suggests that future deep $JWST$ observations may identify relatively bright galaxies to much earlier epochs than might have been anticipated.Comment: Submitted to ApJL. Figs. 1 and 2 summarize the candidates, Fig. 3 places the brightness of these systems in context, Fig. 4 shows the morphology, Fig. 5 explores implications for the UVLF. Comments warmly welcome